What to Know About Wellbutrin (Bupropion)

Wellbutrin（bupropion) is an antidepressant that treats a number of conditions. It comes as an immediate-release, sustained-release, or extended-release tablet that is taken orally.

One factor that makes Wellbutrin especially unique among antidepressants is that it doesn't tend to affect your libido and sexual function. In fact, it's often prescribed along with other antidepressants to help counter the sexual side effects found in other types like loss of desire.

Uses

Wellbutrin被食品和药物管理局（FDA）批准治疗严重抑郁症（MDD）和季节性情绪失调（伤心）。

Off-Label Uses

Wellbutrin.is also used off-label to help with symptoms of在tention-deficit/hyperactivity disorder (ADHD)，双相障碍，焦虑和肥胖症。

Additionally, another brand of bupropion (the active ingredient in Wellbutrin) called Zyban is used to help peoplequit smoking。其他OFF标签用途有时包括社交焦虑症，PTSD，甚至某种形式的神经疼痛。

在服用之前

Wellbutrin通常用作治疗重大抑郁症和季节性情感障碍的一线抗抑郁药。您的医生将评估您的症状和当前健康状况，以确定Wellbutrin是否适合您。

预防措施和禁忌症

Your doctor may not prescribe this drug if you have certain health conditions.

• 如果你有饮食障碍，你不应该妥善洗脑，角度闭合青光眼或癫痫发作障碍。
• 具有双相情感障碍的人可能会增加风险在服用Wellbutrin后经历躁狂，混合或疥疮发作。虽然Bupropion有时被处方标签以治疗抑郁发作，但不批准治疗双相抑郁症。具有双相情感障碍的人也可能在服用后经历自杀思想的风险增加。
• 您的医生可能推荐减少剂量如果你有肾脏问题，肾脏疾病或肝脏问题的历史。
• Never take Wellbutrin if you have a known allergy到了一个bupropion。如果您开始过敏症状，如皮疹，肿胀，荨麻疹，瘙痒和呼吸困难，您应该立即联系紧急服务。
• The drug should not be used by breastfeeding women或儿童。

Wellbutrin是一种妊娠C类药物，其意味着它已被证明对动物研究中的胎儿产生不利影响，并且已经进行了不够的研究以确定它可能在人类中的效果。

出于这个原因，如果您的医生确定潜在的利益超过风险，则该药物应仅在怀孕期间使用。

其他NDRIs

Among antidepressants, bupropion is in a category all its own—it's the only medication in its class, called norepinephrine-dopamine reuptake inhibitors (NDRIs), that boosts the neurotransmitters norepinephrine and dopamine.

经过contrast, selective serotonin reuptake inhibitors (SSRIs) like Prozac (fluoxetine) and Zoloft (sertraline) affect serotonin, while serotonin and norepinephrine reuptake inhibitors (SNRIs) such as Cymbalta (duloxetine) and Effexor (venlafaxine) boost norepinephrine and serotonin.

剂量

Wellbutrin在三种不同的配方中提供，每种版本的剂量变化：

• Immediate release:The regular formulation, simply named Wellbutrin, is an immediate release medication, which means that it begins to work shortly after you take it. Because it acts quickly, it can be taken up to three times a day. This formulation is used to treat major depressive disorder (MDD). A starting dose is usually 100mg taken twice a day and potentially increased to 100mg taken three times a day. The maximum dose is 150mg per single dose.
• 持续释放：Wellbutrin SR，持续的释放版本，也可以治疗MDD。该配方通常每天一次150mg开始，并且每天潜在地增加至150毫克。它可以增加到每天两次服用200毫克。
• Extended-release：Taken once a day, Wellbutrin XL is used to treat MDD and to prevent seasonal affective disorder (SAD). It's typically started out as a dose of 150mg once a day and can be increased to 300mg or even 450mg maximum, both taken once a day.

修改

在某些情况下，由于可能的副作用或其他健康问题，您的医生可能会规定药物的改性剂量。

• 肝脏障碍：对于具有中度至严重肝脏损伤的人，剂量通常降至每天75毫克的最大剂量。
• 随着肾问题：如果您有肾脏损伤，您的医生也可能降低您的剂量或使用频率。
• 在毛泽东之后或之前：If you have previously taken a monoamine oxidase inhibitor (MAOI) or are switching to an MAOI, you should allow 14 days between the discontinuation of your previous drug and the initiation of your new treatment.

如何采取和存储

您应该随时服用您的药物。必要时可以断开立即释放井丁蛋白片剂，但它们足够小，通常不足。药物可以空腹或用食物服用，应在室温下储存，保护免于光和水分。

If you happen to miss a dose of bupropion, take it as soon as you remember. Any remaining doses for the day should be taken at least four hours apart. Never take two doses at once to make up for a missed dose. Taking two doses at the same time can increase your risk of experiencing a seizure or an accidental overdose.

副作用

任何形式的Wellbutrin都没有副作用，其中一些是严肃的。如果您的医生为您列出Wellbutrin，请注意要注意哪些症状。

Some are merely bothersome and likely to disappear as your system gets used to the medication, but others may be serious and should prompt you to call your doctor right away to let them know that you're having problems.

常见的

可能发生副作用，但随着身体调整，它们通常会在几周内消失。Wellbutrin，Wellbutrin SR和Wellbutrin XL的最常见的副作用包括：

• 腹痛
• 焦虑
• 食欲损失
• Changes in the way food tastes
• Constipation
• Dizziness
• Drowsiness
• Dry mouth
• 冲洗
• 气体
• 脱发
• Headache
• 增加出汗
• 失眠
• Joint aches
• 恶心
• 紧张
• 烦躁不安
• Ringing in your ears
• 颤抖
• 小便比平常更多
• Vomiting
• 弱点
• 减肥

Severe

Wellbutrin的一些副作用可能是严重甚至可能危及生命的危及生命。立即获取医疗帮助，如果您在拍摄任何版本的Wellbutrin时遇到以下任何一种：

• 过敏反应，包括皮疹;麻疹;瘙痒;呼吸困难;胸部紧绷的感觉;嘴巴，脸或舌头肿胀;和/或不寻常的声音 - 所有迹象都可能对药物具有严重过敏反应的迹象
• Aggressiveness
• Agitation
• Changes in menstrual cycle
• 性欲或功能的变化
• Changes in vision
• 胸痛
• Confusion
• 暗尿
• Delusions or hallucinations
• 呼吸困难
• Exaggerated feelings of well-being
• 晕倒
• 发烧，寒冷或喉咙痛
• 听证会问题
• 敌意
• Impulsiveness
• Inability to sit still
• Pale-colored stools
• 惊恐发作
• Rapid or irregular heartbeat
• Seizures
• Severe headache
• 严重或挥之不去的关节或肌肉疼痛
• 严重或挥之不去的恶心，呕吐或胃痛
• 严重或挥之不致的紧张，躁动或失眠
• 肿胀，起泡或剥皮皮肤
• 故障集中
• 不寻常的肿胀
• 恶化抑郁和/或自杀思想
• 黄色皮肤或眼睛

警告和互动

Seizures and suicidal thoughts are two of the most serious potential side effects of Wellbutrin.癫痫发作是罕见的这种药物，但确实意识到癫痫发作的风险大约是与其他抗抑郁药的井蛋白大约四倍。

因此，如果您有或癫痫发作，让您的医生知道您的医生会尤为重要;您服用包含Bupropion的任何其他药物，例如Zyban（用于戒烟）;或者，由于这些疾病更容易发生，因此您具有或患有厌食症或贪食症的饮食障碍。

如果您有孩子妥善洗过或另一种治疗抑郁药，请保持近视的迹象自我伤害or自杀思维。

Interactions

当其他物质与Wellbutrin同时采用其他物质时，存在许多潜在的相互作用。其他药物可能会影响安卓酮的作用或增加副作用的风险。这些包括：

• Adderall (amphetamine and dextroamphetamine)
• Antipsychotics such as Risperdal (risperidone) or Haldol (haloperidol)
• 血液稀释剂
• 皮质类固醇包括泼尼松
• Diabetes medications including Glucophage (metformin)
• Monoamine oxidase inhibitors (MAOIs)
• OTC疼痛的解脱，如布洛芬
• 其他抗抑郁药，包括Prozac（Flyoxetine），Zoloft（萨拉序）和Effexor（Venlafaxine）
• Thyroid medications such as Synthroid (levothyroxine)

Using Wellbutrin with alcohol may also influence the frequency and severity of side effects, including seizures and suicidal thoughts.

来自粗糙的一个词

你的医生检查一下关于任何副作用you're experiencing with Wellbutrin if they're severe, bothersome, get worse, or don't go away. Again, the most common ones are the least serious and are likely to be temporary. Get help right away if you have any side effects that could be serious or life-threatening.

在任何一种情况下，直到你先与医生检查一下，不要停止服用。脱离任何抗抑郁药的冷火鸡会导致你的症状回来或变得更糟。

此外，突然停止会导致停药综合症那一系列流感样症状，如胃部不适，头痛，奇怪的感觉和肌肉疼痛。如果您需要停止服用Wellbutrin，您的医生将指导您逐渐逐渐减少。