什么是ndri？

Norepinephrine-多巴胺再摄取抑制剂（NDRIS）是一类主要用于治疗抑郁症的药物。

它们还可用于治疗注意力缺陷多动障碍（ADHD），抑郁症，肿瘤梗死和帕金森病。

They are a newer class of antidepressants used to treat depression and tend to have fewer side effects than other common antidepressants.

What NDRIs Do

Norepinephrine and dopamine are chemical messengers in the brain that might cause mood disorders like depression and anxiety when they malfunction.

NDRIs work by inhibiting the reuptake of norepinephrine and dopamine into the brain.

虽然它们类似于其他再摄取抑制剂药物，如选择性血清素再摄取抑制剂（SSRIS）和血清素 - 去甲肾上腺素再摄取抑制剂（SNRIS），但它们都抑制了化学信使的再缓解，他们专注于抑制去甲肾上腺素和多巴胺而不是血清素。

They do this by blocking the actions of the norepinephrine and dopamine transporters.

用途

当SSRIS这样的其他形式的抗抑郁药时通常使用NDRIS不会产生有效的结果或引起麻烦的副作用。它们通常用于治疗以下条件：

• 沮丧：用于治疗抑郁症的最常见的NDRI是Bupropion.。它的副作用比其他抗抑郁剂更少，但可能不会像治疗更严重的抑郁症一样有效。2016年综述51项对抗抑郁药的约束效果的研究发现，药物是单独的或与其他治疗抑郁症的其他抗抑郁药有效。
• ADHD：有时抗抑郁药有时以刺激药物治疗ADHD症状。Wellbutrin is the most common NDRI used to treat ADHD。It might sometimes be prescribed alongside other ADHD medication like Adderall.
• Narcolepsy：Narcolepsy是一种导致过度白天嗜睡的条件。2019年，FDA批准桑索斯(solriamfetol),这是一个NDRI for the treatment of narcolepsy. Solirameftol helps promote wakefulness in people with this condition.
• 帕金森病了: Sometimes Parkinson’s disease is accompanied by depression. In these cases, NDRIs might be used to treat the depressive symptoms in people who have the disorder.
• 戒烟：如果您发现自己无法戒烟，通过纯粹的旨意，这可能是因为您已经向尼古丁开发了瘾，这在卷烟中大量被发现。NDRIS被批准帮助您通过减少尼古丁的渴望来戒烟。

NDRIS的类型

There are currently three main types of NDRIs approved for use in the United States for different conditions.

Dexmethylphenidate

Dexmethylylanates.are drugs that are typically used for the treatment of ADHD. It can also be used to treat some form of depression.

Dexmethylphenidate的品牌版本是Focalin.。It’s essential to know that Focalin can be habit-forming.

You shouldn’t take it for longer than prescribed or take more quantities than your prescription advises.

Some of the most common side effects you might experience when using Focalin include nausea, dizziness, heartburn, and headaches.

Methylphenidate

Methylphenidate是一种用于治疗成人和儿童的ADHD的药物。它通常以品牌名称出售Ritalin。

利他林也用于治疗成人嗜病。您也可能识别麦克伦特等其他品牌名称，如协奏曲，甲虫和转化酸盐。

Methylphenidate is typically used alongside other treatment options like behavior therapy when being used to treat ADHD. It helps to increase the attention span and reduce symptoms of hyperactivity and impulsivity in people with the condition.

Bupropion

可用药物的最常见的品牌名称是Wellbutrin。Wellbutrin主要用于治疗主要的抑郁症。它也常用于标签以治疗ADHD。

Bupropion目前是唯一批准对食用责任抑郁症的股份有限公司。它也可以根据Zyban和Alpezin等其他品牌名称提供。

2016年对Bupropion作为抑郁症治疗的疗效综述，发现该药物在其自身或其他抑郁症治疗中既有抑郁症状治疗抑郁症状。

Wellbutrin is often used together with an SSRI for treating depression. In 1997, the FDA also approved it for use as a smoking cessation aid, to help people with nicotine dependence quit smoking.

与上述列出的其他NDRI包括：

• Survector (amineptine)
• Cleofil(苯托雷司)
• 葡萄糖植物（Fencamfamine）
• Fapotropil（Phenylpiracetam）
• Catovit (prolintane)

副作用

NDRIs are a commonly preferred treatment option for depression because they have fewer side effects that are common to other antidepressants such as sexual dysfunction.

然而，NDRIS确实会导致一些副作用大多数温和，并且往往会在几周内使用。

• 头痛
• Weight loss
• Anxiety
• 口干
• 便秘
• 失眠
• 出汗
• Loss of appetite
• Nausea
• 呕吐

使用NDRI时可能经历的其他一些严重的副作用包括视力丢失，癫痫发作和震颤。

警告和互动

在使用这种药物时，留意你的血压是必不可少的，因为它有时会导致高血压。长时间使用NDRIS也会导致对药物的依赖性，使您难以撤回。

If your doctor notices you are developing a dependency on the medication, your doctor will no longer prescribe it to you or they will reduce your dosage.

When you stop using an NDRI after a dependency has already developed, you might experience some withdrawal symptoms like headaches, anxiety, insomnia, tiredness, nausea, and vomiting.

使用时使用NDRI单胺氧化酶抑制剂强烈警告。在某些情况下，它会导致血清素综合征，由某些药物组合引起的潜在危及生命的病症。

使用NDRI时使用抗精神病药性可能会增加开发癫痫发作的风险。