How Long Does Tramadol Stay in Your System?

Tramadol is a synthetic阿片类药物镇痛药用来治疗中度至中度严重的疼痛。它可根据品牌名称提供，包括Conzip，Fusepaq Synapryn，Rybix，Ryzolt和Ultram。了解系统中保持多长时间可以帮助您了解避免药物相互作用和可能过量的预防措施。这种药物适用于儿童的担忧，所以和你的医生讨论这一点。

与Xanax（Alprazolam）和Valium（Diazepam）一样，曲马多被归类为美国的时间表IV药物，这意味着即使在规定的剂量上也具有较低的成瘾和滥用可能性。

Tramadol is not screened for on standard 5-panel and 10-panel drug tests, however, it will show up on other drug tests for prescription pain medications. There is a special concern with this medication being used for children, so discuss its use with your doctor.

感受到效果需要多长时间？

Tramadol works on the opioid pain receptors in your brain and throughout yourcentral nervous system。It also weakly inhibits the reuptake of two neurotransmitters: serotonin and norepinephrine.

疼痛缓解效果在两到4小时内剂量和峰后开始大约一小时。还有曲马多的曲折型浮雕版本，可在较长的时间内分配剂量。这意味着单个扩展救济丸在系统中的行为更长。

虽然它是活跃的，但曲马多压抑呼吸并导致学生收缩。它降低了消化系统中的动力，因此食物需要更长的消化，您可能会遇到便秘。它扩张了你的血管，你可能有冲洗，瘙痒，出汗，红色的眼睛，并且在躺下后起床时会有头晕或晕眩体验。

How Long Does Tramadol Last?

根据这一点FDA， 这半衰期of tramadol in the blood is between five and nine hours, and even longer for people who have been taking multiple doses. The half-life is the time it takes half of a dose to be eliminated by the body. Complete elimination takes about five to six times as long as the half-life.

曲马多被肝脏分解在肝脏中，主要被尿液中的肾脏排出。约30％的剂量被排泄不变。其余的被转化为多个代谢物，然后再排出。

血液

血液测试可以在使用后最快地检测曲马多，通常在最后使用后长达48小时。

Urine

曲马多通常在尿液中可检测一至四天。

Saliva

Tramadol can be detected in saliva for up to 48 hours after the last use.

头发

毛囊测试可以检测系统中的曲马多，长达90天。

假阳性测试

虽然没有多少物质可以引发曲马多，曲马多及其代谢物可以引发诸如此类物质的其他物质的假阳性卡式肺囊虫肺炎和Buprenorphine.。As a result, you will want to alert your testing facility in advance that you are prescribed tramadol.

影响检测时间的因素

About 7% of people are "poor metabolizers" of tramadol, due to reduced activity of the CYP2D6 isoenzyme of cytochrome P-450. For people in this population, it takes significantly longer to break down tramadol as well as tricyclic antidepressants and other drugs.

结果，它们在血液中有更活跃的药物较长的时间。如果采取其他药物进一步减少分解曲马多的酶的作用，这些人面临风险。

曲马多的药丸形式被身体吸收较慢，也比下降或注射形式更缓慢地排出。此外，还有其他因素可以影响药物的检测时间，包括：

• Age: The elderly metabolize more slowly, may take additional medications that affect metabolism, and are also at a higher risk for impaired kidney or liver function. All of these factors usually result in a slower metabolism for older people.
• 剂量: Higher doses will take longer to metabolize.
• 使用频率: Tramadol accumulates in the body as more doses are taken; if some of the previous doses haven't completely broken down, your body will likely take longer to metabolize additional doses.
• Metabolism: A slower metabolic rate will increase the amount of time it takes tramadol to break down; activity level, diet, and body composition can all affect metabolism.
• 减少肾脏或肝功能: Impairment of the organs the body uses to get rid of waste will increase the amount of time tramadol stays in your body.

How to Get Tramadol Out of Your System

与流行的信仰相反，锻炼或饮用水不会帮助您将曲马多的曲折性速度更快，以“击败”药物测试。让曲马多的曲折的唯一方法是停止服用药物并让您的身体时间来处理和消除它。

If you suspect anoverdoseof tramadol, administering Narcan (naloxone), often available at local health departments as a nasal spray, will inhibit the dangerous effects of too much tramadol on the respiratory system, though it will not speed up the elimination of the tramadol. Keep this in mind as it may be necessary to administer additional doses of naloxone if enough tramadol remains in the body.

Symptoms of Overdose

为了防止过量的曲马多，您只需在规定的时间表上取得规定的金额。粉碎或切割延长的释放片剂或胶囊是危险的，因为这样做会释放一次较大的剂量。

曲马多剂量的症状可包括：

• Blue or purplish-black fingernails and lips
• 寒冷，粘性皮肤
• Constricted pupils
• Making a snore-like gurgling noise or choking sounds
• Muscle weakness
• 对刺激的不响应
• 脉冲（心跳）慢，不稳定，或不可检测
• Seizures
• 慢，浅，不稳定或停止呼吸
• Unconsciousness

曲马多与许多其他药物相互作用，这可能导致危及生命的健康问题，包括呼吸问题，镇静和昏迷。特别关注的是与之相互作用苯二氮卓卓，单胺氧化酶抑制剂（MAOIS），和酒精。

讨论您采取的所有药物，计划采取，或计划停止与医生接管，所以可以筛选和调整，以防止危险的互动。不要喝酒，服用含酒精的药物，或使用街头药物，同时服用曲马多或危险，可能会危及危及危及生命的互动。

得到帮助

如果您突然停止使用，您可能会经历戒断症状如焦虑，肌肉疼痛和疼痛，过度出汗和失眠。Tarmadol戒断可以在最后剂量后一到两天开始，第三天之后的峰值，并在一到两周内消退。当时停止使用曲马多避免这些症状时，您的医生将提供停止时间表。

即使在规定的情况下服用，曲马多带有高依赖性的风险。治疗方案opiate use disorder包括：

• Harm reduction psychotherapy
• Medication-assisted treatment (MAT) with buprenorphine or methadone
• 旨在帮助您以可持续的方式关闭鸦片方案的计划

When transitioning off of opioids like tramadol, your doctor may prescribe other medications to ease withdrawal symptoms and prevent breakthrough pain.