Grapefruit Interactions With Bipolar Drugs

葡萄柚汁似乎可能是一个理想的饮料，为一个美味的美国早餐，但是当谈到洗手的双极药物时，再次想一想。与某些类型的柑橘类水果不同，葡萄柚可能会干扰某些药物的代谢，无意中增加它们的浓度至潜在的毒性水平。

Bipolar drugsare not the only ones affected. Also on the no-fly list are medications used to treat everything from high cholesterol and arrhythmia to allergies and HIV. Even Viagra is complicated by the otherwise healthy effects of grapefruit.

Impact

A number ofpsychotropic drugs那including those used treat焦虑那depression那andpsychosis，是80种药物葡萄柚汁中已知干扰。四十三种药物具有严重的不良影响。

这是因为葡萄柚含有furanocoumarins, an organic compound that blocks an enzyme that normally breaks down certain medications. While other citrus fruits like pomelos, limes, and Seville oranges also contain furanocoumarins, they haven't been studied as closely.

效果的程度和持久性

The degree by which grapefruit can affect certain drugs can vary. For some medications, one small glass of juice can result in what would be equivalent to a double or triple dose.

For example, as much as 99% of BuSpar (buspirone) is normally metabolized before the drug enters the bloodstream. When taken with grapefruit juice, the concentration can increase by as much as 400%. Or, as demonstrated in this research, four-fold.

与此同时，葡萄柚的影响可能是持久的，在摄入后几小时到几天的某些药物与某些药物相互作用。或者，您可以完全避免葡萄柚并用（非塞维利亚）橙汁替代。

Grapefruit and some of the related citrus canirreversibly抑制酶。这些药物应该不是用葡萄柚或任何相关的柑橘类食用，或者应该在任何相关的柑橘类药物或替代药物。

虽然它可能纯粹是推测最脆弱的患者可能是谁，但是超过45岁的人是葡萄柚的主要购买者，并获得最多的药物处方。

受影响的药物清单

所有人都说，有十几种药物常用于treat symptoms of bipolar disorderthat are known to be affected, in differing degrees, by grapefruit.

• Anafranil（Clomipramine）
• Buspar（Buspirone）
• Elavil（amitiptyline）
• 卤素（三唑仑）
• Luvox (fluvoxamine)
• Prozac (fluoxetine)
• Seroquel (quetiapine)
• Serzone（Nefazodone）
• Tegretol（Carbamazepine）
• 曲唑酮（Desyrel）
• valium（Diazepam）
• Versed（咪达唑仑）
• Zoloft（萨拉里林）

Always read the packet insert in its entirety to understand which interactions can occur. Typically, you can find this in or around the fifth paragraph where it would read: "Talk with your doctor before including grapefruit or grapefruit juice in your diet while you are taking this medicine."

来自粗糙的一个词

每年，越来越多的药物被确定为具有与葡萄柚的可能相互作用。最后，如果明智地拍摄，通常仍然可以享受葡萄柚，并享受其维生素C，纤维，钾，番茄红素和胆碱组合的好处。如果有疑问，请与您的医生交谈。